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7 new mutations in KIT found, including two more TB DW!!

Posted: Fri May 15, 2009 2:21 pm
by RiddleMeThis
Here is the article directly to the paper, but you have to pay for it
http://www3.interscience.wiley.com/jour ... 1&SRETRY=0

Here is a very good summary done by Dun Central Station (warning PDF)
http://www.duncentralstation.com/PDF/KI ... Castle.pdf

Posted: Fri May 15, 2009 5:54 pm
by Desert Oasis Sporthorses
Thank you so much for this information. It really helps.

Posted: Fri May 15, 2009 8:24 pm
by summerhorse
Awesome, thanks!!!!!!!!!!!!

Posted: Fri May 15, 2009 9:47 pm
by xfactor fan
Thanks so much for posting.

Interesting about the new TB families.
Anyone care to speculate on who the unnamed families are?

Wonder if they've tested the white Sunday Silence mare?

Posted: Sat May 16, 2009 12:43 am
by color
Can someone please explain in easy words for a German???

Posted: Sat May 16, 2009 7:33 am
by xfactor fan
Color,

There is an area on equine chromosome 3 that has a number of color related genes. This region is called KIT.

The study looks at white horses, and found that pure white horses can be either maximum sabino, or Dominant White.

Dominant White horses can be pure white, or white mixed with their basecoat colors. This is a new mutation in the KIT gene, and not related to Sabino.

They seem to have found 11 different mutations of Dominant White. So they have found families of white horses that all appear to be Dominant White, but have slightly different mutations.

Each mutation is in slightly different location of the KIT gene.

All the horses that have been studied have only one copy of the Dominant White mutation, leading to the belief that two copies of the mutation lead to early embryo death.

Donna's Puchi Trap horses are Dominant White, not Sabino. The Patchen Beauty horses are also Dominant White.

There are two other TB families mentioned as being Dominant White, but none of the horses in those families are named.

Hope this helps.

Posted: Sat May 16, 2009 8:41 am
by Georgerz
This is getting me confused: I thought that Puchi Trap's progeny were dilute, not white.

Posted: Sat May 16, 2009 10:23 am
by RiddleMeThis
Georgerz wrote:This is getting me confused: I thought that Puchi Trap's progeny were dilute, not white.


They are theorized to be both.

Puchi Trap was not listed in the study as being tested for Dominant White however Puchilingui IS dominant white as is Sato and it is theorized that because of her markings and because of her family she is also Dominant White.

Now while her offspring ARE dilute they are most likely ALSO Dominant White.

Despite the name not all dominant white horses are 100% white.

Sato for example, is dominant white AND palomino, just like many of the horses we talk about here are Bay and Sabino, or Gray and Sabino
Image

Posted: Sat May 16, 2009 10:25 am
by Lucy
Georgerz wrote:This is getting me confused: I thought that Puchi Trap's progeny were dilute, not white.


I could be mistaken, but if I read the article correctly, carrying the DW gene doesn't always mean you get an all-white horse. Puchi Trap's excessive white markings can also be a result. So, they can still have the dilute gene working on the bits that aren't white.

I'd imagine that it would take a test to tell if a horse whith high whites/belly spots/etc. is carring the DW, or sabino?

Posted: Sat May 16, 2009 10:43 am
by color
This is confusing me totally. So my all white mares Padrama and Shew are not max Sabinos but Dominant Whites? And dominant whites can produce all kind of white stuff from minimal to maximal and that is what we formerly called Sabino? So then WHAT is Sabino ??? And where starts and end the one and the other?????? HEEEELP

Posted: Sat May 16, 2009 10:47 am
by color
My mare Dressed To Dance f.e. is not coming from any of the white lines and she has excessive white like Puchi Trap but if following the above article she cannot be one of these genetics. So what is she then?

The colt by The Alchemist and Shew which is totally white and underneath a Palomino is then a Dominant White Palomino????

Posted: Sat May 16, 2009 10:58 am
by RiddleMeThis
color wrote:This is confusing me totally. So my all white mares Padrama and Shew are not max Sabinos but Dominant Whites?
Possibly, depending on their pedigree.
And dominant whites can produce all kind of white stuff from minimal to maximal and that is what we formerly called Sabino?


So then WHAT is Sabino ??? And where starts and end the one and the other?????? HEEEELP


No dominant white is NOT sabino. The main difference is in how the act.

Dominant white is theorized to be embryonic lethal in its homozygous state, and you only need one copy to have a solid white horse.

Sabino white is not lethal in its homozygous state and you need two copies of it to ave a solid white horse.

So what is she then?
She could be sabino, or she could be a different form of dominant white, as its proving to be a very common mutation.

The colt by The Alchemist and Shew which is totally white and underneath a Palomino is then a Dominant White Palomino????
If Shew is dominant white then yes her foal is probably a dominant white palomino.

ETA:I just went and looked at those mares, and based on their pedigree, and looks I would bet they, and their produce, are Dominant White.

Posted: Sat May 16, 2009 11:57 am
by xfactor fan
It might help to think of white as an extra, not a color.

Sato for example is a red horse + a single dilute (cream) and then the white comes and on top of the base coat and stops pigment from working.

So, here's the mechanics of what he looks like.

Red--Dilute to Palomino--White stop all pigment.

And pretty much in that order.

He's going to pass on his red base coat to all his offspring, his Cream gene to 50% of his offspring, and the Dominant White to 50% of his offspring.

Posted: Sat May 16, 2009 5:53 pm
by Jorge
RiddleMeThis

I want to add my voice to acknowledge and express gratitude for this valuable and interesting reference. Great! Bravo!
All the Best,



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Posted: Sat May 16, 2009 7:00 pm
by Desert Oasis Sporthorses
As I have mentioned before, thanks for all the information. It is great. I see that the Puchilingui line is dominant white. However, it is mentioned here that there are two other lines that are dominant white but not named. How do we find out? My reasons are because I have two from the Airdrie line. I also have a foal due from the Puchilingui line. The information would help me make a decision as to what to do with the foal since the dominant white appears to lethal in embryonic stage. Can anyone provide insight as to the other lines? Thanks. And please, keep the information coming!!!