Bute and Lasix

[AfleetAlex]

Do bute and lasix counteract with eachother?

"Countless scientific studies have shown that furosemide (Lasix) effectively reduces pulmonary hemorrhage in horses with EIPH ("bleeders"). When phenylbutazone is given along with the furosemide, the pulmonary artery pressures rise back up to the values seen prior to giving the furosemide; it's as if you never gave the Lasix if you give Bute with it. "

I have read this a few times and I know A LOT of trainers use both. Does anyone have any expierence with this? What do you guys think of it?

[Danzig]

WTF?

[griff]

I read an article recently that said Lasix was a much better enhancer than a protector from pulmenary hemorrhaging

griff

[cng]

The effect of premedication with phenylbutazone on systemic hemodynamic and diuretic effects of furosemide was examined in 6 healthy, conscious, mares. Mares were instrumented for measurement of systemic hemodynamics, including cardiac output and pulmonary arterial, systemic arterial, and intracardiac pressures, and urine flow. Each of 3 treatments was administered in a randomized, blinded study; furosemide (1 mg/kg of body weight, IV) only, phenylbutazone (8.8 mg/kg, PO, at 24 hours and 4.4 mg/kg, IV, 30 minutes before furosemide) and furosemide, or 0.9% NaCl. Phenylbutazone administration significantly attenuated, but did not abolish, the diuretic effect of furosemide. Phenylbutazone completely inhibited the immediate effect of furosemide on cardiac output, stroke volume, total peripheral resistance, and right ventricular peak pressure. Premedication with phenylbutazone did not inhibit equally the diuretic and hemodynamic effects of furosemide, indicating that some of furosemide's hemodynamic effects are mediated by an extrarenal activity of furosemide.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus

[Tiz]

In my area, bute is withdrawn 24 hours prior to the race. Lasix is administered at 4 hours prior. It appears the study shows bute cancels lasix only if administered together.

[Roger]

In my area, bute is withdrawn 24 hours prior to the race. Lasix is administered at 4 hours prior. It appears the study shows bute cancels lasix only if administered together.

This is good info, I hope we can get an answer to your question Tiz.