http://www.thoroughbredtimes.com/racing ... -Brea.aspx
I love when the article calls the fact that HY died of a heart condition "a grim coincidence"
Really? Could it be, say, hereditary maybe?
High Again, daughter of High Yield. Heart issues?
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High Again, daughter of High Yield. Heart issues?
All shouting does is make you lose your voice.
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going4stamina
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Actually, this is my understanding of the situation...and I feel there is at least a need to keep it on the radar:
After a lot of research....
Vasquez-Osler Syndrome (what the French Connections said High Yield had), is most likely caused by a chromosomal issue. It has been renamed Polycythemia Vera (PV) to better describe the conditions. The most common cause of death in this situation is Thrombosis, a clot in a blood vessel restricting the flow of blood, leading to a heart attack. PV is a preleukemia like syndrome caused by genetic changes in the stem cells. As a "patient" ages, the increase in the changes in the stem cells causes the symptoms to become apparent (not found as a young person or horse). In humans, at least 85% of patients are found to have some chromosomal abnormality (the other 15% may have a chromosomal abnormality also, but they can be difficult to find in the chromosomal test).
PV is certainly an inherited trait. There are three ways High Yield could have this:
1) inherited chromosomal abnormality from Storm Cat
2) inherited chromosomal abnormality from his dam, Scoop the Gold
3) genetic mutation in High Yield in the embryo
In any of these cases, it is at least possible for this condition to be inherited by at least 50% of High Yield's progeny.
Of interest: In 2007...
2 yo Storm Cat colt - 2/25/07 collapsed and died on track while working in Calder Under Tack show for FT FL Select 2 YO in Training Sale. U of F found cause to be intestinal aneurysm. (could be caused by an undiagnosed PV case)
2 yo Chestnut Colt Hip #194 3/12/07 Barretts March Selected 2 year old in training sale - (Hold That Tiger - Wancha Back, by End Sweep) - collapsed on track during under tack show. Necropsy results showed ruptured artery. (could be caused by an undiagnosed PV case). Hold That Tiger is a son of Storm Cat
Angola - 5/15/07 at 3. Collapsed following race at Philadelphia Park and was euthanized due to complications of heat stroke and colic. By Black Minnaloushe, a Storm Cat son...remotely possible (not altogether likely) that could have been linked to undiagnosed PV.
Cat's at Home - Died suddenly on 3/24/07 at age 10 (apparent heart attack) at Windfield's Farm, ON. He will be buried at Windfield's Farm. Grandson of Storm Cat
Hennessy--died of apparent heart attack at 14
Sailor's Warning, SC son died of heart attack at age 6
Tabasco Cat died of heart attack at 13
***I have no idea what happened to Harlan? Anybody else know what happened?****
These are just the cases I know of, most in the last year..too little info to make a conclusive judgement...but I would have some reservations about SC or at very least High Yield.
After a lot of research....
Vasquez-Osler Syndrome (what the French Connections said High Yield had), is most likely caused by a chromosomal issue. It has been renamed Polycythemia Vera (PV) to better describe the conditions. The most common cause of death in this situation is Thrombosis, a clot in a blood vessel restricting the flow of blood, leading to a heart attack. PV is a preleukemia like syndrome caused by genetic changes in the stem cells. As a "patient" ages, the increase in the changes in the stem cells causes the symptoms to become apparent (not found as a young person or horse). In humans, at least 85% of patients are found to have some chromosomal abnormality (the other 15% may have a chromosomal abnormality also, but they can be difficult to find in the chromosomal test).
PV is certainly an inherited trait. There are three ways High Yield could have this:
1) inherited chromosomal abnormality from Storm Cat
2) inherited chromosomal abnormality from his dam, Scoop the Gold
3) genetic mutation in High Yield in the embryo
In any of these cases, it is at least possible for this condition to be inherited by at least 50% of High Yield's progeny.
Of interest: In 2007...
2 yo Storm Cat colt - 2/25/07 collapsed and died on track while working in Calder Under Tack show for FT FL Select 2 YO in Training Sale. U of F found cause to be intestinal aneurysm. (could be caused by an undiagnosed PV case)
2 yo Chestnut Colt Hip #194 3/12/07 Barretts March Selected 2 year old in training sale - (Hold That Tiger - Wancha Back, by End Sweep) - collapsed on track during under tack show. Necropsy results showed ruptured artery. (could be caused by an undiagnosed PV case). Hold That Tiger is a son of Storm Cat
Angola - 5/15/07 at 3. Collapsed following race at Philadelphia Park and was euthanized due to complications of heat stroke and colic. By Black Minnaloushe, a Storm Cat son...remotely possible (not altogether likely) that could have been linked to undiagnosed PV.
Cat's at Home - Died suddenly on 3/24/07 at age 10 (apparent heart attack) at Windfield's Farm, ON. He will be buried at Windfield's Farm. Grandson of Storm Cat
Hennessy--died of apparent heart attack at 14
Sailor's Warning, SC son died of heart attack at age 6
Tabasco Cat died of heart attack at 13
***I have no idea what happened to Harlan? Anybody else know what happened?****
These are just the cases I know of, most in the last year..too little info to make a conclusive judgement...but I would have some reservations about SC or at very least High Yield.
I'm stealing a post from another thread because someone else there explained that the Osler's reference means something different in France:
Here is the thread if you'd like to take a look: http://thoroughbredchampions.com/forum/ ... ic=22040.0
I actually don't think that's it. The French reference said "maladie d'Osler," and if you google for that, you get:
L'endocardite infectieuse d'Osler
[?] Qu'est-ce que c'est ?
C'est l'infection des valvules cardiaques par des bact?ries.
Le d?pistage de l'endocardite d'Osler doit ?tre rapide car il s'agit d'une urgence.
Malheureusement, la moiti? des cas ne sont diagnostiqu?s qu'apr?s un mois d'?volution et une endocardite sur dix n'est d?pist?e qu'apr?s 6 mois.
La maladie atteint plus souvent l'homme de plus de 50 ans.
This, too, is the human version, but it's endocarditis-- a bacterial infection of the heart valves. That is much more consistent with the French racing report that it was a heart infection, and I'm sure it's what they meant rather than HHT.
Here is the thread if you'd like to take a look: http://thoroughbredchampions.com/forum/ ... ic=22040.0
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going4stamina
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